منابع مشابه
Evaluation of Exhausted Regulatory T Cells in Preeclampsia
Background: The development of a maternal immune response to fetal antigens and deficiency in regulatory T-cells (Tregs) may lead to preeclampsia. A plausible explanation for the reduced Treg cell function in women with preeclampsia is the presence of exhausted Treg cells which express CD279 or programmed cell death receptor-1 (PD-1), a negative regulatory molecule associated w...
متن کاملSetting up Exhausted Values
This paper argues that exhaustification is empirically and theoretically important as a tool in the semantic description of various constructions in natural language. Discussion focuses on the comparative construction, and presents a view of exhaustification as a ‘control element’ that influences the interpretation of a more basic element: the existential quantifier.
متن کاملRejuvenating Exhausted T Cells during Chronic Viral Infection
In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.
متن کاملCD4+ T Cells are Exhausted and Show Functional Defects in Chronic Lymphocytic Leukemia
Background: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become “exhausted” and characterized with poor effector functions and the expression of multiple inhibitory receptors. Objective: To inve...
متن کاملCD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD3...
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ژورنال
عنوان ژورنال: Nature
سال: 2006
ISSN: 0028-0836,1476-4679
DOI: 10.1038/439669a